Ziyuglycoside I
Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics[1]. Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53, it can be a potential agent candidate for treating triple-negative breast cancer (TNBC) [2].
Product Specifications
CAS Number
35286-58-9
UNSPSC
12352005
Target
Apoptosis; MDM-2/p53
Type
Natural Products
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ziyuglycoside-i.html
Purity
99.42
Solubility
DMSO : 100 mg/mL (ultrasonic) |Methanol : 125 mg/mL (ultrasonic)
Smiles
O[C@@H]1[C@@H](O)[C@]([H])(O[C@@H]2C(C)(C)[C@@](CC[C@]3(C)[C@]4([H])CC=C5[C@@]3(C)CC[C@]6(C(O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)=O)[C@@]5([H])[C@@](O)(C)[C@H](C)CC6)([H])[C@]4(C)CC2)OC[C@@H]1O
Molecular Formula
C41H66O13
Molecular Weight
766.96
References & Citations
[1]Kim YH, et al. Anti-wrinkle activity of ziyuglycoside I isolated from a Sanguisorba officinalis root extract and its application as a cosmeceutical ingredient. Biosci Biotechnol Biochem. 2008 Feb;72 (2) :303-11. Epub 2008 Feb 7.|[2]Zhu X, et al. Ziyuglycoside I Inhibits the Proliferation of MDA-MB-231 Breast Carcinoma Cells through Inducing p53-Mediated G2/M Cell Cycle Arrest and Intrinsic/Extrinsic Apoptosis. Int J Mol Sci. 2016 Nov 22;17 (11) . pii: E1903
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
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