Eprosartan (mesylate)

Eprosartan mesylate (SKF-108566J) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan mesylate binds angiotensin II receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively[1].

Product Specifications

CAS Number

[144143-96-4]

Product Name Alternative

SKF-108566J

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Angiotensin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Eprosartan-mesylate.html

Purity

99.95

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC(/C(CC1=CC=CS1)=C/C2=CN=C(CCCC)N2CC3=CC=C(C(O)=O)C=C3)=O.CS(=O)(O)=O

Molecular Formula

C24H28N2O7S2

Molecular Weight

520.62

Precautions

H302, H315, H319, H335

References & Citations

[1]R M Edwards, et al. Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566. J Pharmacol Exp Ther. 1992 Jan;260 (1) :175-81.