Rabbit anti Human Ceramide Glycosyltransferase
Product Specifications
Background
Ceramide Glycosyltransferase may serve as a flippase as well as a glucosyltransferase that transfers glucose to ceramide. It Catalzes; UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine. Ceramide Glycosyltransferase is the first step in the Glycosphingolipid synthesis; first glycosylation step. Glucosylceramide synthase (GlcT) and lactosylceramide synthase (GalT) are key enzymes for the synthesis of major glycosphingolipids of vertebrates.
Synonyms
Glucosylceramide synthase, GCS, UDP glucose N-acylsphingosine D glucosyltransferase, GLCT-1, UDP glucose ceramide glucosyltransferase
UniProt
Q16739
Host
Rabbit
Species Reactivity
Human
Conjugation
Unconjugated
Type
Polyclonal Antibody
Source
Rabbits were immunized with a synthetic peptide derived from Human ceramide glycosyltransferase protein.
Applications
WB, ELISA
Field of Research
Signal Transduction
Purification Method
Ammonium Sulfate Precipitation
Assay Principle
Antibody can be used for Western blotting (5-10µg/mL) and ELISA. Other applications not yet tested. Optimal concentration should be evaluated by serial dilutions.
Stability
See expiration date on vial
Concentration
See vial for Concentration
Form
Provided as solution in phosphate buffered saline with 0,08% sodium azide
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
References & Citations
1. Expression cloning of a cDNA for Human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis.; Ichikawa S., Sakiyama H., Suzuki G., Hidari K.I.-P., Hirabayashi Y.; Proc. Natl. Acad. Sci. U.S.A. 93:4638-4643(1996)._x000D_
2. van Vlerken, L.E., et al. ‘Modulation of Intracellular Ceramide Using Polymeric Nanoparticles to Overcome Multidrug Resistance in Cancer.’ Cancer Res., 67, 4843-4850, (2007).
Shipping Conditions
Ambient Temperature, freeze upon arrival
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
WB
CAS Number
9007-83-4
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