[pSer2, pSer5, pSer7]-CTD (TFA)
[pSer2, pSer5, pSer7]-CTD (TFA), a substrate for CDK7 (cyclin dependent protein kinase), is a phosphorylated polypeptide at ser2, ser5 and ser7 sites of RNA polymerase II carboxy-terminal domain (CTD) [1].
Product Specifications
UNSPSC
12352209
Target
CDK
Type
Peptides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pser2-pser5-pser7-ctd-tfa.html
Solubility
H2O
Smiles
OC(C=C1)=CC=C1C[C@H](NC([C@H](COP(O)(O)=O)NC([C@H]2N(CCC2)C([C@H](COP(O)(O)=O)NC([C@H]([C@H](O)C)NC([C@H]3N(CCC3)C([C@H](COP(O)(O)=O)NC([C@@H](N)CC4=CC=C(C=C4)O)=O)=O)=O)=O)=O)=O)=O)C(N[C@@H](CO)C(N5[C@@H](CCC5)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N6[C@@H](CCC6)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CO)C(N7[C@@H](CCC7)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N8[C@@H](CCC8)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)CC9=CC=C(C=C9)O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
Molecular Formula
C98H141F3N21O48P3
Molecular Weight
2531.20
References & Citations
[1]Czudnochowski N, et al. Serine-7 but not serine-5 phosphorylation primes RNA polymerase II CTD for P-TEFb recognition. Nat Commun. 2012 May 15;3:842.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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