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Nifekalant (hydrochloride) (Standard)

Nifekalant (hydrochloride) (Standard) is the analytical standard of Nifekalant (hydrochloride) . This product is intended for research and analytical applications. Nifekalant hydrochloride (MS-551), a class III antiarrhythmic agent, is a IKr potassium channel blocker with an IC50 of 10 µM. Nifekalant hydrochloride can be used for refractory ventricular tachyarrhythmias research[1][2].

Product Specifications

CAS Number

[130656-51-8]

Product Name Alternative

MS-551 (Standard)

UNSPSC

12352005

Target

Potassium Channel; Reference Standards

Type

Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/nifekalant-hydrochloride-standard.html

Smiles

[H]Cl.O=C1N(C)C(C=C(NCCN(CCO)CCCC2=CC=C([N+]([O-])=O)C=C2)N1C)=O

Molecular Formula

C19H28ClN5O5

Molecular Weight

441.91

References & Citations

[1]Lü-Pei Du, et al. The pharmacophore hypotheses of I (Kr) potassium channel blockers: novel class III antiarrhythmic agents. Bioorg Med Chem Lett. 2004 Sep 20;14 (18) :4771-7.|[2]Ioannis N Pantazopoulos, et al. Nifekalant in the treatment of life-threatening ventricular tachyarrhythmias. World J Cardiol. 2011 Jun 26;3 (6) :169-76.|[3]J Chen, et al. IK independent class III actions of MS-551 compared with sematilide and dofetilide during reperfusion in anaesthetized rats. Br J Pharmacol. 1996 Nov;119 (5) :937-42.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

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