VU6036864
VU6036864 (compound 45) is an orally active, selective mAChR M5 antagonist with IC50=20 nM for human M5. VU6036864 is >500-fold selective for human M1-4, with BBB characteristic and high oral bioavailability (%F>100%) [1].
Product Specifications
CAS Number
2746406-36-8
UNSPSC
12352005
Target
MAChR
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
CC1=NC=C(S(=O)(N2C([2H])([2H])CC(C3=CN4C(C=C3Cl)=NC=N4)CC2([2H])[2H])=O)O1
Molecular Formula
C15H12D4ClN5O3S
Molecular Weight
385.86
References & Citations
[1]Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M5 Muscarinic Acetylcholine Receptor
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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