Hm1a
Hm1a is a disulfide-rich spider-venom peptide, and a NaV1.1 activator. Hm1a restores the function of inhibitory interneurons in Dravet syndrome (DS) mouse model[1].
Product Specifications
UNSPSC
12352209
Target
Sodium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hm1a.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC(C)C)C(N[C@H]2CO)=O)=O)=O)=O)NC3=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@@H](CC(C)C)C(N[C@@H](CC5=CC=CC=C5)C(NCC(NCC(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CC6=CNC7=CC=CC=C67)C(N[C@@H](CCCCN)C(N[C@H]8CC9=CC=C(C=C9)O)=O)=O)=O)=O)=O)=O)NC2=O)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@H]3CSSC[C@@H](C(N[C@@H](C)C(N[C@@H](CC%10=CNC%11=CC=CC=C%10%11)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H](CC%12=CC=CC=C%12)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)NC8=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(O)=O)N
Molecular Formula
C170H239N47O54S6
Molecular Weight
3997.39
References & Citations
[1]Chow CY, et al. A selective NaV1.1 activator with potential for treatment of Dravet syndrome epilepsy. Biochem Pharmacol. 2020 Nov;181:113991.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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