Human TIM-4 Extracellular Domain Biotinylated

<strong>Human TIM-4 Extracellular Domain Biotinylated</strong>_x000D_ <strong>Catalog number:</strong> B2016781_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 20 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 32.7 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> T Cell Immunoglobulin and Mucin Domain-containing Protein 4, T Cell Immunoglobulin Mucin Receptor 4, T Cell Membrane Protein 4, TIMD-4_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Moon B, Yang S, Kim K, Lee J, Jeong D, Park D. EphA2 Interacts with Tim-4 through Association between Its FN3 Domain and the IgV Domain of Tim-4 Cells. 2021 May 22;10(6):1290._x000D_ 2: Fang XY, Xu WD, Pan HF, Leng RX, Ye DQ. Novel insights into Tim-4 function in autoimmune diseases Autoimmunity. 2015 Jun;48(4):189-95._x000D_ 3: Cieniewicz B, Bhatta A, Torabi D, Baichoo P, Saxton M, Arballo A, Nguyen L, Thomas S, Kethar H, Kukutla P, Shoaga O, Yu B, Yang Z, Fate M, Oliveira E, Ning H, Corey L, Corey D. Chimeric TIM-4 receptor-modified T cells targeting phosphatidylserine mediates both cytotoxic anti-tumor responses and phagocytic uptake of tumor-associated antigen for T cell cross-presentation Mol Ther. 2023 Jul 5;31(7):2132-2153._x000D_ 4: Mesri M, Smithson G, Ghatpande A, Chapoval A, Shenoy S, Boldog F, Hackett C, Pena CE, Burgess C, Bendele A, Shimkets RA, Starling GC. Inhibition of in vitro and in vivo T cell responses by recombinant human Tim-1 extracellular domain proteins Int Immunol. 2006 Mar;18(3):473-84._x000D_ 5: Cao W, Ryan M, Buckley D, O'Connor R, Clarkson MR. Tim-4 inhibition of T-cell activation and T helper type 17 differentiation requires both the immunoglobulin V and mucin domains and occurs via the mitogen-activated protein kinase pathway Immunology. 2011 Jun;133(2):179-89._x000D_ 6: Omori S, Tsugita M, Hoshikawa Y, Morita M, Ito F, Yamaguchi SI, Xie Q, Noyori O, Yamaguchi T, Takada A, Saitoh T, Toyokuni S, Akiba H, Nagata S, Kinoshita K, Nakayama M. Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation Cell Rep. 2021 Feb 9;34(6):108734._x000D_ 7: Xiao L, Fu ZR, Liu F, Zhang LD, Shi XM, Shen XY, Ni ZJ, Fu H, Li RD, Cao XT, Ding GS, Wang QX. Suppression of allograft rejection by Tim-1-Fc through cross-linking with a novel Tim-1 binding partner on T cells PLoS One. 2011;6(7):e21697._x000D_ 8: Hishida S, Kawakami K, Fujita Y, Kato T, Takai M, Iinuma K, Nakane K, Tsuchiya T, Koie T, Miura Y, Ito M, Mizutani K. Proteomic analysis of extracellular vesicles identified PI3K pathway as a potential therapeutic target for cabazitaxel-resistant prostate cancer Prostate. 2021 Jun;81(9):592-602._x000D_ 9: Klaas M, Dubock S, Ferguson DJP, Crocker PR. Sialoadhesin (CD169/Siglec-1) is an extended molecule that escapes inhibitory cis-interactions and synergizes with other macrophage receptors to promote phagocytosis Glycoconj J. 2023 Apr;40(2):213-223._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/18367551">10: Mizui M, Shikina T, Arase H, Suzuki K, Yasui T, Rennert PD, Kumanogoh A, Kikutani H. Bimodal regulation of T cell-mediated immune responses by TIM-4 Int Immunol. 2008 May;20(5):695-708. </a>_x000D_ _x000D_ <strong>Products Related to Human TIM-4 Extracellular Domain Biotinylated can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>