AGN 191976
AGN 191976 is a potent and selective thromboxane A2-sensitive (TP) receptor agonist with EC50 values of 0.23 nM and 24 nM in rat aorta and human platelets, respectively. AGN 191976 has potent IOP-lowering effects in dogs and monkeys. AGN 191976 can be used to study vascular biology and the role of thromboxane A2 in vascular function[1].
Product Specifications
CAS Number
159359-94-1
UNSPSC
12352005
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/agn-191976.html
Smiles
O=C(CCC/C=C\C[C@H]1[C@]2(OC(O[C@@]([H])([C@@H]1/C=C/[C@H](CCCCC)O)C2)=O)[H])O
Molecular Formula
C21H32O6
Molecular Weight
380.48
References & Citations
[1]KRAUSS, et al. "AGN 191976: a novel thromboxane A2-mimetic with ocular hypotensive properties." Journal of ocular pharmacology and therapeutics 11.3 (1995) : 203-212.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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