HOE 689
HOE 689 (Ramnodigin) is an analog of Digitoxin. HOE 689 exhibits cytotoxicity to lung cancer cells and induces apoptosis in cancer cell NCI-H460 with an IC50 of 52 nM[1].
Product Specifications
CAS Number
33156-28-4
Product Name Alternative
Ramnodigin
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hoe-689.html
Smiles
O[C@@]12[C@@]3([H])[C@@](CC[C@@]1([C@@H](C(CO4)=CC4=O)CC2)C)([H])[C@@]5([C@](C[C@H](CC5)O[C@@H]6O[C@H]([C@@H](CC6)O)C)([H])CC3)C
Molecular Formula
C29H44O6
Molecular Weight
488.66
References & Citations
[1]Wang HY, et al., C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity. ACS Med Chem Lett. 2011 Apr 14;2 (4) :259-263.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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