Sinomenine hydrochloride
Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation[1]. Sinomenine also is an activator of μ-opioid receptor[2].
Product Specifications
CAS Number
6080-33-7
Product Name Alternative
Cucoline hydrochloride
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; NF-κB; Opioid Receptor
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Sinomenine_hydrochloride.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic; warming) |H2O : 16.67 mg/mL (ultrasonic)
Smiles
OC(C1=C2C[C@@]3([H])[C@](C=C4OC)([H])[C@@]1(CCN3C)CC4=O)=C(C=C2)OC.Cl
Molecular Formula
C19H24ClNO4
Molecular Weight
365.85
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
NF-κB; μ Opioid Receptor/MOR
Citation 01
Available Sizes
Frequently Asked Questions
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