Panaxadiol (Standard)

Panaxadiol (Standard) is the analytical standard of Panaxadiol. This product is intended for research and analytical applications. Panaxadiol (20 (R) -Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities[1][2].

Product Specifications

CAS Number

[19666-76-3]

Product Name Alternative

20 (R) -Panaxadiol (Standard)

UNSPSC

12352005

Target

HIF/HIF Prolyl-Hydroxylase; PD-1/PD-L1; Reference Standards; STAT

Type

Reference Standards

Related Pathways

Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; Others; Stem Cell/Wnt

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/panaxadiol-standard.html

Smiles

C[C@@]1(CC[C@@H]2O)[C@](C[C@H]3O)([H])[C@](CC[C@@]1([H])C2(C)C)(C)[C@@]4(C)[C@@]3([H])[C@]([C@](CCC5)(C)OC5(C)C)([H])CC4

Molecular Formula

C30H52O3

Molecular Weight

460.73

References & Citations

[1]Wang Z, et al. Panaxadiol inhibits programmed cell death-ligand 1 expression and tumour proliferation via hypoxia-inducible factor (HIF) -1α and STAT3 in human colon cancer cells. Pharmacol Res. 2020;155:104727.|[2]Myong Hak Ri, et al. Development of natural products for anti-PD-1/PD-L1 immunotherapy against cancer. J Ethnopharmacol. 2021 Dec 5;281:114370.