Cortisol sulfate

Cortisol sulfate (Cortisol 21-sulfate) is a metabolite of Cortisol (HY-N0583) . Cortisol sulfate is a specific ligand for intracellular transcortin[1][2][3].

Product Specifications

CAS Number

[1253-43-6]

Product Name Alternative

Cortisol 21-sulfate

UNSPSC

12352100

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/cortisol-sulfate.html

Solubility

10 mM in DMSO

Smiles

C[C@]([C@@]1(O)C(CO[S](=O)(O)=O)=O)(C2)[C@](CC1)([H])[C@@](CCC3=CC4=O)([H])[C@]([C@]3(CC4)C)([H])[C@H]2O

Molecular Formula

C21H30O8S

Molecular Weight

442.52

References & Citations

[1]C S Hall, et al. Simultaneous metabolism of cortisol sulfate and cortisol in normal human adults. J Clin Endocrinol Metab. 1970 Oct;31 (4) :439-44.|[2]S S Singer, et al. Enzymatic sulfation of steroids: I. The enzymatic basis for the sex difference in cortisol sulfation by rat liver preparations. Endocrinology. 1976 Apr;98 (4) :963-74.|[3]T Hayashi, et al. Cortisol-21-sulfate (FS) is a specific ligand for intracellular transcortin: demonstration of three types of high affinity corticosteroid binders in bovine aortic cytosol by a combined use of FS and RU 28362. Endocrinology. 1990 Jan;126 (1) :307-16.|[4]S Miyabo, et al. Behavioral and other systemic effects of cortisol-21 sulfate. Horm Behav. 1972 Sep;3 (3) :227-36.