GS-9148

GS-9148 is a ribose-modified HIV-1 nucleotide reverse transcriptase (RT) inhibitor with an EC50 value of 10.6 µM. GS-9148 shows antiretroviral activity for K65R, L74V, or M184V RT mutation[1].

Product Specifications

CAS Number

[875608-25-6]

UNSPSC

12352005

Target

HIV; Reverse Transcriptase

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/gs-9148.html

Smiles

OP(O)(CO[C@H]1O[C@H](C(F)=C1)N2C=NC3=C(N=CN=C23)N)=O

Molecular Formula

C10H11FN5O5P

Molecular Weight

331.20

References & Citations

[1]Cihlar T, et al. Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131. Antimicrob Agents Chemother. 2008 Feb;52 (2) :655-65.