Dicycloplatin
Dicycloplatin is a DNA damage inducer. Dicycloplatin induces DNA damage by activating biphosphorylated checkpoint kinase 2 (CHK2), breast cancer 1 (BRCA1) and triphosphorylated p53. Dicycloplatin can induce cell cycle arrest, inhibit proliferation and lead to apoptosis in prostate cancer PC3 cells and lung cancer NCI/H446 cells. Dicycloplatin can be used in cancer researchr[1].
Product Specifications
CAS Number
287402-09-9
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dicycloplatin.html
Smiles
O=C(C1(CCC1)C(O)=O)O.O=C2[O-][Pt+2]([NH3])([NH3])[O-]C(C23CCC3)=O
Molecular Formula
C12H20N2O8Pt
Molecular Weight
515.38
References & Citations
[1]Yu J J, et al. Dicycloplatin, a novel platinum analog in chemotherapy: synthesis of chinese pre-clinical and clinical profile and emerging mechanistic studies[J]. Anticancer Research, 2014, 34 (1) : 455-463.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Frequently Asked Questions
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