STING-IN-8
Product Specifications
UNSPSC Description
STING-IN-8 (Compound 15b) emerges as a potent stimulator of interferon gene (STING) inhibitor with an IC50 value of 0.121 μM in human and an IC50 value of 0.033 μM in mouse. STING-IN-8 inhibits MSA-2 (HY-136927) or 2’, 3’ -cGAMP (HY-100564)-stimulated STING signaling and suppresses immune-inflammatory cytokine levels in both human and murine cells. STING-IN-8 is promising for research in the field of STING-associated inflammatory and autoimmune diseases[1].
Target Antigen
STING
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sting-in-8.html
Smiles
CS(=O)(NC1=C(C=CC(NC(C2=NC(C3=CC=C(C=C3)OC(F)(F)F)=CS2)=O)=C1)O)=O
Molecular Weight
473.45
References & Citations
[1]Jin Z, et al. Design, synthesis, and evaluation of thiazolecarboxamide derivatives as stimulator of interferon gene inhibitors[J]. Mol Divers. 2024 Apr 29, 1573-501X
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163749/STING-IN-8-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163749/
Clinical Information
No Development Reported
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