(−) -N-Hydroxyapiosporamide
(−) -N-Hydroxyapiosporamide (NHAP), an alkaloid, is an NF-κB inhibitor with potent antitumor activity in vitro and in vivo. (−) -N-Hydroxyapiosporamide can be used for the research of colorectal cancer (CRC) [1].
Product Specifications
CAS Number
1205676-02-3
Product Name Alternative
NHAP
UNSPSC
12352005
Target
NF-κB
Type
Natural Products
Related Pathways
NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n-hydroxyapiosporamide.html
Solubility
10 mM in DMSO
Smiles
O=C([C@]1([C@]2([C@@]([H])(C[C@@H](CC2)C)C=C[C@H]1C)[H])[H])C3=C(C([C@@]4([C@H]5[C@@H]([C@@H](CC4)O)O5)O)=CN(O)C3=O)O
Molecular Formula
C24H31NO7
Molecular Weight
445.51
References & Citations
[1]Feng L, et al. The Natural Alkaloid (-) -N-Hydroxyapiosporamide Suppresses Colorectal Tumor Progression as an NF-κB Pathway Inhibitor by Targeting the TAK1-TRAF6 Complex. J Nat Prod. 2023 Jun 23;86 (6) :1449-1462.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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