PTK7/β-catenin-IN-1

PTK7/β-catenin-IN-1 (compound 01065) is a potent PTK7/β-catenin inhibitor with an IC50 of 8.9 μM and 56.5 μM for PTK7/β-catenin and p53/MDM2, respectively. PTK7/β-catenin-IN-1 has the potential for cancer research[1].

Product Specifications

CAS Number

[906147-24-8]

UNSPSC

12352005

Target

β-catenin

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ptk7-β-catenin-in-1.html

Purity

99.99

Solubility

DMSO : 60 mg/mL (ultrasonic)

Smiles

O=C(C(C1=CNC2=C1C=CC=C2)=O)NC3=C(C4=CC=CC=C4)C=CC=C3

Molecular Formula

C22H16N2O2

Molecular Weight

340.37

References & Citations

[1]Laetitia Ganier, et al. Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer. ACS Chem Biol. 2022 May 20;17 (5) :1061-1072.