PTK7/β-catenin-IN-1
Product Specifications
UNSPSC Description
PTK7/β-catenin-IN-1 (compound 01065) is a potent PTK7/β-catenin inhibitor with an IC50 of 8.9 μM and 56.5 μM for PTK7/β-catenin and p53/MDM2, respectively. PTK7/β-catenin-IN-1 has the potential for cancer research[1].
Target Antigen
β-catenin
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ptk7-β-catenin-in-1.html
Solubility
DMSO : 60 mg/mL (ultrasonic)
Smiles
O=C(C(C1=CNC2=C1C=CC=C2)=O)NC3=C(C4=CC=CC=C4)C=CC=C3
Molecular Weight
340.37
References & Citations
[1]Laetitia Ganier, et al. Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer. ACS Chem Biol. 2022 May 20;17(5):1061-1072.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-160488/PTK7-β-catenin-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-160488/PTK7-β-catenin-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
906147-24-8
Available Sizes
Curated Selection
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