PTK7/β-catenin-IN-1
PTK7/β-catenin-IN-1 (compound 01065) is a potent PTK7/β-catenin inhibitor with an IC50 of 8.9 μM and 56.5 μM for PTK7/β-catenin and p53/MDM2, respectively. PTK7/β-catenin-IN-1 has the potential for cancer research[1].
Product Specifications
CAS Number
[906147-24-8]
UNSPSC
12352005
Target
β-catenin
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ptk7-β-catenin-in-1.html
Purity
99.99
Solubility
DMSO : 60 mg/mL (ultrasonic)
Smiles
O=C(C(C1=CNC2=C1C=CC=C2)=O)NC3=C(C4=CC=CC=C4)C=CC=C3
Molecular Formula
C22H16N2O2
Molecular Weight
340.37
References & Citations
[1]Laetitia Ganier, et al. Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer. ACS Chem Biol. 2022 May 20;17 (5) :1061-1072.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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