PAT-505

PAT-505 is a potent, selective, noncompetitive and orally available autotaxin inhibitor, with an IC50 of 2 nM in Hep3B cells, 9.7 nM in human blood and 62 nM in mouse plasma.

Product Specifications

CAS Number

[1782070-22-7]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/PAT-505.html

Concentration

10mM

Purity

99.47

Solubility

DMSO : 48.33 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC=CC(SC2=C(C3CC3)N(C4=CN(CC)N=C4)C5=C2C=CC(Cl)=C5F)=C1F

Molecular Formula

C23H18ClF2N3O2S

Molecular Weight

473.92

References & Citations

[1]Bain G, et al. Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis. J Pharmacol Exp Ther. 2017 Jan;360 (1) :1-13. Epub 2016 Oct 17.