Dazostinag (disodium)
Dazostinag disodium (TAK-676) is an agonist of STING, triggering the activation of STING signaling pathway and type I interferons. Dazostinag disodium is also a modulator of immune system, resulting complete regressions and durable memory T-cell immunity. Dazostinag disodium promotes durable IFN-dependent antitumor immunity[1].
Product Specifications
CAS Number
[2553413-93-5]
Product Name Alternative
TAK-676
UNSPSC
12352005
Target
STING
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dazostinag-disodium.html
Purity
99.67
Solubility
H2O : ≥ 100 mg/mL
Smiles
FC1=CN([C@H]2[C@H](O[P@@](OC[C@@H]3[C@@H](O4)[C@@H](F)[C@H](N5C6=NC=NC(N)=C6N=C5)O3)([S-])=O)[C@H](O)[C@@H](COP4([S-])=O)O2)C7=C1C(N=CN7)=O.[Na+].[Na+]
Molecular Formula
C21H20F2N8Na2O10P2S2
Molecular Weight
754.48
References & Citations
[1]Elizabeth CC, et al. TAK-676: A Novel Stimulator of Interferon Genes (STING) Agonist Promoting Durable IFN-dependent Antitumor Immunity in Preclinical Studies. Cancer Research Communications. 2022. 2 (6) : 489–502.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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