SEH/HDAC6-IN-1
SEH/HDAC6-IN-1 (compound M9) is a selective, orally active dual inhibitor for sEH and HDAC6, with IC50s of 2 nM, 0.72 nM and 5 nM, for human sEH, murine sEH and HDAC6, respectively. sEH/HDAC6-IN-1 reveals analgesic and anti-inflammatory effects[1].
Product Specifications
CAS Number
2847838-67-7
UNSPSC
12352005
Target
Epoxide Hydrolase; HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/seh-hdac6-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NC(C=C1)=CC=C1C(NCCCCCCC(NO)=O)=O)N[C@@](C[C@]2(C3)C)(C[C@H]3C4)C[C@]4(C2)C
Molecular Formula
C27H40N4O4
Molecular Weight
484.63
References & Citations
[1]Chen Y, et al., Design and Synthesis of Dual-Targeting Inhibitors of sEH and HDAC6 for the Treatment of Neuropathic Pain and Lipopolysaccharide-Induced Mortality. J Med Chem. 2024 Feb 8;67 (3) :2095-2117.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC11; HDAC2; HDAC3; HDAC6
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