YH-53
YH-53 is a potent 3CLpro inhibitor with Ki values of 6.3 nM, 34.7 nM for SARS-CoV-1 3CLpro and SARS-CoV-2 3CLpro, respectively. YH-53 strongly blocks the SARS-CoV-2 replication. YH-53 is a peptidomimetic compound with a unique benzothiazolyl ketone. YH-53 has the potential for COVID-19 research[1][2].
Product Specifications
CAS Number
1471484-62-4
UNSPSC
12352005
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/yh-53.html
Purity
98.78
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
COC1=C2C(NC(C(N[C@@H](CC(C)C)C(N[C@@H](C[C@H]3C(NCC3)=O)C(C4=NC5=CC=CC=C5S4)=O)=O)=O)=C2)=CC=C1
Molecular Formula
C30H33N5O5S
Molecular Weight
575.68
References & Citations
[1]Sho Konno, et al. 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents. J Med Chem. 2021 Jul27; acs.jmedchem.1c00665.|[2]Pillaiyar Thanigaimalai, et al. Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: design, synthesis, biological evaluation, and docking studies. Eur J Med Chem. 2013 Oct;68:372-84.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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