HDAC8-IN-10
HDAC8-IN-10 (compound 15) is a potent inhibitor of HDAC8, with the IC50 of 7.6 nM. HDAC8-IN-10 is a HDAC8 target protein ligand that can be used to synthesize PROTAC YX862.
Product Specifications
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac8-in-10.html
Smiles
CCCCCCNNC(C(C=C1)=CC=C1N2CCN(C)CC2)=O
Molecular Formula
C18H30N4O
Molecular Weight
318.46
References & Citations
[1]Yufeng Xiao, et al. Discovery of a Highly Potent and Selective HDAC8 Degrader: Advancing the Functional Understanding and Therapeutic Potential of HDAC8. J Med Chem. 2024 Jul 1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC8
Frequently Asked Questions
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