WEE1-IN-7
WEE1-IN-7 (compound 12h) is a potent and orally activeWEE1 inhibitor with an IC50 value of 2.1 nM. WEE1-IN-7 induces apoptosis and cell cycle arrest at the S phase. WEE1-IN-7 shows antitumor activity[1].
Product Specifications
CAS Number
2924006-98-2
UNSPSC
12352005
Target
Apoptosis; Wee1
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wee1-in-7.html
Purity
99.7000
Solubility
DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=CN=C(NC3=CC=C(N4CCN(CC4)C)C=C3)N=C2N(N1CC=C)C5=CC=CC(C6=NC=CN=C6)=N5
Molecular Formula
C28H28N10O
Molecular Weight
520.59
References & Citations
[1]Wang Y, et al. Advanced Design, Synthesis, and Evaluation of Highly Selective Wee1 Inhibitors: Enhancing Pharmacokinetics and Antitumor Efficacy. J Med Chem. 2024 Jun 7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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