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Givosiran (sodium)

Givosiran (ALN-AS1) sodium is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran sodium downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid (ALA) and porphobilinogen (PBG) levels. Givosiran sodium demonstrates potent inhibitory activity against ALAS1 in mouse, rat, and cynomolgus monkey models. Givosiran sodium can be used for the research of acute hepatic porphyria (AHP) [1][2].

Product Specifications

CAS Number

1639325-44-2

Product Name Alternative

ALN-AS1 (sodium)

UNSPSC

12352208

Target

Small Interfering RNA (siRNA)

Type

Oligonucleotides

Related Pathways

Epigenetics

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/givosiran-sodium.html

Purity

98.71

Solubility

10 mM in H2O

Smiles

[Givosiran(sodium)]

Molecular Formula

C524H650F16N173Na44O316P43S6

Molecular Weight

16300.60 (free acid)

References & Citations

[1]Scott LJ. Givosiran: First Approval. Drugs. 2020 Feb;80 (3) :335-339.|[2]Chan A, et al. Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA Quantification. Mol Ther Nucleic Acids. 2015 Nov 3;4 (11) :e263.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Oligonucleotides

Clinical Information

Launched

Available Sizes

Frequently Asked Questions

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