Tenovin-6 (Hydrochloride)
Tenovin-6 Hydrochloride, an analog of Tenovin-1 , is an activator of p53 transcriptional activity. Tenovin-6 Hydrochloride inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC50s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 Hydrochloride also inhibits dihydroorotate dehydrogenase (DHODH)[2].
Product Specifications
CAS Number
1011301-29-3
UNSPSC
12352005
Hazard Statement
H315, H317, H318, H334, H335, H341, H361, H370, H413
Target
Autophagy; Dihydroorotate Dehydrogenase; MDM-2/p53; Sirtuin
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Tenovin-6-Hydrochloride.html
Purity
98.88
Solubility
DMSO : ≥ 49 mg/mL
Smiles
O=C(NC(NC1=CC=C(NC(CCCCN(C)C)=O)C=C1)=S)C2=CC=C(C(C)(C)C)C=C2.Cl
Molecular Formula
C25H35ClN4O2S
Molecular Weight
491.09
Precautions
H315, H317, H318, H334, H335, H341, H361, H370, H413
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT1; SIRT2; SIRT3
Available Sizes
Frequently Asked Questions
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