IL-17A antagonist 1
IL-17A antagonist 1 (compound 1) is an IL-17A antagonist, with a Kd of 0.66 μM and an IC50 of 1.14 μM[1].
Product Specifications
CAS Number
[2205034-18-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Interleukin Related
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/IL-17A_antagonist_1.html
Concentration
10mM
Purity
99.74
Solubility
DMSO : 41.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N(C)C)CC1(CC(NCCC2=CC=C(NC([C@H](CC3=CC=CC=C3F)NC(C4=CC=NN4C)=O)=O)C=C2)=O)CCCC1
Molecular Formula
C33H41FN6O4
Molecular Weight
604.71
Precautions
H302, H315, H319, H335
References & Citations
[1]Liu S, et al. Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists. Sci Rep. 2016 Aug 16;6:30859.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-17
Available Sizes
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