Neratinib (Standard)

Neratinib (Standard) is the analytical standard of Neratinib. This product is intended for research and analytical applications. Neratinib (HKI-272) is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively[1].

Product Specifications

CAS Number

[698387-09-6]

Product Name Alternative

HKI-272 (Standard)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

EGFR; Reference Standards

Type

Reference Standards

Related Pathways

JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/neratinib-standard.html

Purity

99.25

Smiles

ClC1=C(OCC2=NC=CC=C2)C=CC(NC3=C(C#N)C=NC4=CC(OCC)=C(NC(/C=C/CN(C)C)=O)C=C43)=C1

Molecular Formula

C30H29ClN6O3

Molecular Weight

557.04

Precautions

H302, H315, H319, H335

References & Citations

[1]Rabindran SK, et al. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res, 2004, 64 (11), 3958-3965.