MRL-871
MRL-871 (compound 3) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 12.7 nM. MRL-871 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells[1].
Product Specifications
CAS Number
1392809-08-3
Product Name Alternative
(±)-4-Hydroxy Propranolol-d7 (hydrochloride),(±)-4-Hydroxy Propranolol-d17
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mrl-871.html
Purity
99.11
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C(C=C1)C2=NN(C3=C2C=CC=C3)C(C4=C(C=CC=C4Cl)C(F)(F)F)=O)O
Molecular Formula
C22H12ClF3N2O3
Molecular Weight
444.79
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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