4′-DTMP
Product Specifications
UNSPSC Description
4 '-DTMP is a DHFR inhibitor with Ki of 5.1 nM (DHFRWT) and 34.3 nM (DHFRL28R), respectively. 4 '-DTMP carries a polar modification that induces additional local interactions with the enzyme. In particular, the hairpin structure on the M20 ring is related to the internal communication of the DHFR. 4 '-DTMP has potential inhibition of E.coli[1].
Target Antigen
Dihydrofolate reductase (DHFR)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/4-dtmp.html
Purity
97.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=C(OC)C=C(CC2=CN=C(N)N=C2N)C=C1OC
Molecular Weight
276.296
References & Citations
[1]Cetin E, et al. Kinetic Barrier to Enzyme Inhibition Is Manipulated by Dynamical Local Interactions in E. coli DHFR. J Chem Inf Model. 2023 Aug 14;63(15):4839-4849.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W587663/4-DTMP-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W587663/4-DTMP-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
21253-58-7
Available Sizes
Curated Selection
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