Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Hu CD172a PerCP-Cy™5.5

Selected Variant

T9-798-T100

Size: 100 Tests

CD172a, the signal-regulatory protein alpha (SIRP alpha), also known as SH2 domain-containing phosphatase substrate-1 (SHPS1), is a 75-110 kDa transmembrane glycoprotein expressed mainly on granulocytes, monocytes, macrophages, dendritic cells and neurons. Its extracellular ligand is CD47. CD172a serves as a substrate of activated receptor tyrosine kinases and upon phosphorylation it recruits SH2 domain-containing tyrosine phosphatases, thereby regulating signal transduction processes related to cell activation, transmigration and phagocytosis. CD172a is a specific marker of cardiomyocytes derived from human pluripotent stem cells and serves as a negative regulator of signaling and growth in myeloid progenitor cells.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

Kg-1a cell line

Target Antigen

CD172a

Clone

15-414

Applications

FC (QC tested)

Format

PerCP-Cy

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Baba T, Badr Mel S, Tomaru U, Ishizu A, Mukaida N: Novel process of intrathymic tumor-immune tolerance through CCR2-mediated recruitment of Sirpα+ dendritic cells: a murine model. PLoS One. 2012;7 (7) :e41154. doi: 10.1371/journal.pone.0041154., URL: https://www.ncbi.nlm.nih.gov/pubmed/22815949, *Hansen IS, Krabbendam L, Bernink JH, Loayza-Puch F, Hoepel W, van Burgsteden JA, Kuijper EC, Buskens CJ, Bemelman WA, Zaat SAJ, Agami R, Vidarsson G, van den Brink GR, de Jong EC, Wildenberg ME, Baeten DLP, Everts B, den Dunnen J: FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming. Nat Commun. 2018 Feb 28;9 (1) :863., URL: https://pubmed.ncbi.nlm.nih.gov/29491406/

Other References

*Liu Y, Bühring HJ, Zen K, Burst SL, Schnell FJ, Williams IR, Parkos CA: Signal regulatory protein (SIRPalpha), a cellular ligand for CD47, regulates neutrophil transmigration. J Biol Chem. 2002 Mar 22;277 (12) :10028-36., URL: https://pubmed.ncbi.nlm.nih.gov/11792697/, *Seiffert M, Brossart P, Cant C, Cella M, Colonna M, Brugger W, Kanz L, Ullrich A, Bühring HJ: Signal-regulatory protein alpha (SIRPalpha) but not SIRPbeta is involved in T-cell activation, binds to CD47 with high affinity, and is expressed on immature CD34 (+) CD38 (-) hematopoietic cells. Blood. 2001 May 1;97 (9) :2741-9., URL: https://pubmed.ncbi.nlm.nih.gov/11313266/

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody 15-414 recognizes en extracellular epitope of CD172a (SIRP alpha), an approximately 90 kDa transmembrane glycoprotein expressed on cells of myeloid origin and neurons.

Applications Notes

6

Isotype

Mouse IgG2a

Price

Sign In for Pricing

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Human Kappa Light Chain (B-Cell Marker) (rL1C1), 1mg/mL
BNUM2222-50 1x 50 µL

Human Kappa Light Chain (B-Cell Marker) (rL1C1), 1mg/mL

Sign In for Pricing
View Details
Anti-Met (c-Met) Antibody Picoband® (Dylight594 Conjugate)
PB9186-Dylight594 100 µg

Anti-Met (c-Met) Antibody Picoband® (Dylight594 Conjugate)

Sign In for Pricing
View Details
CD5 (Mantle Cell Lymphoma Marker) (CD5/2416), CF405S conjugate, 0.1mg/mL
BNC042416-100 1x 100 µL

CD5 (Mantle Cell Lymphoma Marker) (CD5/2416), CF405S conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Anti-CDC42 Antibody Picoband®
A00119-1 100 µg/Vial

Anti-CDC42 Antibody Picoband®

Sign In for Pricing
View Details
WT1 (Wilm's Tumor 1) (WT1/857 + 6F-H2), CF405M conjugate, 0.1mg/mL
BNC051138-100 1x 100 µL

WT1 (Wilm's Tumor 1) (WT1/857 + 6F-H2), CF405M conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Anti-MEKK2/MAP3K2 Antibody Picoband®
PA1499 100 µg/Vial

Anti-MEKK2/MAP3K2 Antibody Picoband®

Sign In for Pricing
View Details