TAK1/MAP4K2 inhibitor 1
TAK1/MAP4K2 inhibitor 1 is a potent dual TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2) inhibitor, with IC50s of 41.1 nM and 18.2 nM, respectively.
Product Specifications
CAS Number
1315330-11-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAP3K; MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/b-raf-inhibitor.html
Purity
99.91
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(N1)=CC2=C1N=CN=C2OC3=C(C)C=CC(C(NC4=CC=C(CN5CCN(CC)CC5)C(C(F)(F)F)=C4)=O)=C3
Molecular Formula
C29H31F3N6O2
Molecular Weight
552.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Tan L, et al. Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2) . J Med Chem. 2015 Jan 8;58 (1) :183-96.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP3K7/TAK1; MAP4K2/GCK
Available Sizes
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