TAK1/MAP4K2 inhibitor 1

TAK1/MAP4K2 inhibitor 1 is a potent dual TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2) inhibitor, with IC50s of 41.1 nM and 18.2 nM, respectively.

Product Specifications

CAS Number

[1315330-11-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MAP3K; MAP4K

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/b-raf-inhibitor.html

Purity

99.91

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(N1)=CC2=C1N=CN=C2OC3=C(C)C=CC(C(NC4=CC=C(CN5CCN(CC)CC5)C(C(F)(F)F)=C4)=O)=C3

Molecular Formula

C29H31F3N6O2

Molecular Weight

552.59

Precautions

H302, H315, H319, H335

References & Citations

[1]Tan L, et al. Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2) . J Med Chem. 2015 Jan 8;58 (1) :183-96.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MAP3K7/TAK1; MAP4K2/GCK

Available Sizes

Curated Selection

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