Nivalenol-13C15

Nivalenol-13C15 is the 13C labeled Nivalenol (HY-N6801) [1]. Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product[2]. Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect[3].

Product Specifications

CAS Number

[911392-40-0]

UNSPSC

12352005

Hazard Statement

H225-H302+H312+H332-H319

Target

Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/nivalenol-13c15.html

Concentration

76.40 μM * 1.2 mL in Acetonitrile

Solubility

10 mM in DMSO

Smiles

[13CH3][13C@@]12[13C@@]3([13C@]([H])(O[13C@]4([13C@]2([13CH2]O)[13C@H](O)[13C]([13C]([13CH3])=[13CH]4)=O)[H])[13C@H](O)[13C@H]1O)[13CH2]O3

Molecular Formula

13C15H20O7

Molecular Weight

327.20

Precautions

P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P330-P362+P364-P370+P378-P403+P235-P501

References & Citations

[1]Bryła M, et al. Natural Occurrence of Nivalenol, Deoxynivalenol, and Deoxynivalenol-3-Glucoside in Polish Winter Wheat. Toxins (Basel) . 2018 Feb 13;10 (2) .|[2]Aupanun S, et al. Individual and combined mycotoxins deoxynivalenol, nivalenol, and fusarenon-X induced apoptosis in lymphoid tissues of mice after oral exposure. Toxicon. 2019 Jul;165:83-94.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-220.