Irigenin (Standard)

Irigenin (Standard) is the analytical standard of Irigenin. This product is intended for research and analytical applications. Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA) . Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells[1].

Product Specifications

CAS Number

[548-76-5]

UNSPSC

12352005

Target

Apoptosis; Integrin; Reference Standards

Type

Reference Standards

Related Pathways

Apoptosis; Cytoskeleton; Others

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/irigenin-standard.html

Smiles

O=C1C(C2=CC(OC)=C(OC)C(O)=C2)=COC3=CC(O)=C(OC)C(O)=C13

Molecular Formula

C18H16O8

Molecular Weight

360.31

References & Citations

[1]Amin A, et al. Irigenin, a novel lead from Western Himalayan chemiome inhibits Fibronectin-Extra Domain A induced metastasis in Lung cancer cells. Sci Rep. 2016 Nov 16;6:37151.|[2]Xu Y, et al. Irigenin sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells. Biochem Biophys Res Commun. 2018 Feb 12;496 (3) :998-1005.