PA1
PA1 is a photoswitchable epithelial sodium channel (ENaC) blocker. PA1 can switch to cis-PA1 at 400nm and trans-PA1 at 500nm. PA1 inhibits δ/αENaC, αβγENaC, and δβγENaC, with IC50 values of 4.3nM, 90 nM, and 390 nM, respectively[1].
Product Specifications
CAS Number
1620951-72-5
Product Name Alternative
Photoamiloride-1
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pa1.html
Smiles
O=C(NC(NC1=CC=C(C=C1)/N=N/C2=CC=CC=C2)=N)C3=NC(Cl)=C(N=C3N)N
Molecular Formula
C18H16ClN9O
Molecular Weight
409.83
References & Citations
[1]Matthias Schönberger, et al. Controlling epithelial sodium channels with light using photoswitchable amilorides. Nat Chem. 2014 Aug;6 (8) :712-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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