D-Isoleucine

D-Isoleucine is a selective competitive activator of the Asc-1 antiporter (Ki=0.98 mM) . D-Isoleucine promotes the release of D-serine and glycine by binding to the Asc-1 protein on the neuronal cell membrane, and enhances NMDA receptor-dependent synaptic plasticity. D-Isoleucine can be used in the study of neurodegenerative diseases (such as Alzheimer's disease and schizophrenia) . D-Isoleucine also acts as a non-classical D-amino acid, interferes with bacterial peptidoglycan synthesis, and inhibits the formation of Staphylococcus aureus biofilm, and has potential antibacterial application value[1][2].

Product Specifications

CAS Number

[319-78-8]

Product Name Alternative

(R) -Isoleucine

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

ASCT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/d-isoleucine.html

Purity

99.83

Solubility

H2O : 5.56 mg/mL (ultrasonic)

Smiles

CC[C@@H](C)[C@@H](N)C(O)=O

Molecular Formula

C6H13NO2

Molecular Weight

131.18

Precautions

H302, H315, H319, H335

References & Citations

[1]Rosenberg D, et, al. Neuronal D-serine and glycine release via the Asc-1 transporter regulates NMDA receptor-dependent synaptic activity. J Neurosci. 2013 Feb 20;33 (8) :3533-44.|[2]Dörries K, et al. Metabolic footprint analysis uncovers strain specific overflow metabolism and D-isoleucine production of Staphylococcus aureus COL and HG001. PLoS One. 2013 Dec 3;8 (12) :e81500.