GLPG0492
GLPG0492 is a non-steroidal selective androgen receptor modulator (potency 12 nM) . GLPG0492 has the potential for the research of musculo-skeletal diseases such as sarcopenia and cachexia[1][2].
Product Specifications
CAS Number
1215085-92-9
UNSPSC
12352005
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/GLPG0492.html
Purity
99.85
Solubility
DMSO : ≥ 50 mg/mL
Smiles
N#CC1=CC=C(N(C(N(C)[C@]2(CO)C3=CC=CC=C3)=O)C2=O)C=C1C(F)(F)F
Molecular Formula
C19H14F3N3O3
Molecular Weight
389.33
References & Citations
[1]Nique F, et al. Identification of a 4- (hydroxymethyl) diarylhydantoin as a selective androgen receptor modulator. J Med Chem. 2012 Oct 11;55 (19) :8236-47.|[2]Cozzoli A, et al. GLPG0492, a novel selective androgen receptor modulator, improves muscle performance in the exercised-mdx mouse model of muscular dystrophy. Pharmacol Res. 2013 Jun;72:9-24.|[3]Blanqué R, et al. Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization. BMC Musculoskelet Disord. 2014 Sep 3;15:291.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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