(E) -[6]-Dehydroparadol
(E) -[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol , is a potent Nrf2 activator. (E) -[6]-Dehydroparadol can inhibit the growth and induce the apoptosis of human cancer cells[1][2].
Product Specifications
CAS Number
878006-06-5
UNSPSC
12352005
Target
Apoptosis; Keap1-Nrf2
Type
Reference compound
Related Pathways
Apoptosis; NF-κB
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/_E_-[6]-Dehydroparadol.html
Purity
95.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCCCCCC(/C=C/C1=CC=C(O)C(OC)=C1)=O
Molecular Formula
C17H24O3
Molecular Weight
276.37
References & Citations
[1]Chen H, et, al. Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human. Mol Nutr Food Res. 2013 May;57 (5) :865-76.|[2]Zhu Y, et, al. Synthesis, evaluation, and metabolism of novel [6]-shogaol derivatives as potent Nrf2 activators. Free Radic Biol Med. 2016 Jun;95:243-54.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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