Bisindolylmaleimide II
Bisindolylmaleimide II is a general inhibitor of all PKC subtypes[1].
Product Specifications
CAS Number
137592-45-1
Product Name Alternative
Bis II
UNSPSC
12352005
Target
PKC
Type
Reference compound
Related Pathways
Epigenetics; TGF-beta/Smad
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/bisindolylmaleimide-ii.html
Purity
99.80
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C(C1=CNC2=C1C=CC=C2)=C3C4=CN(CCC5N(C)CCC5)C6=C4C=CC=C6)NC3=O
Molecular Formula
C27H26N4O2
Molecular Weight
438.52
References & Citations
[1]Gassel M, et al. The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase A. J Biol Chem. 2004 May 28;279 (22) :23679-90.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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