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Promethazine (hydrochloride) (Standard)

Promethazine (hydrochloride) (Standard) is the analytical standard of Promethazine (hydrochloride) . This product is intended for research and analytical applications. Promethazine hydrochloride is an orally active phenothiazine derivative with antihistaminic (H1), sedative, antiemetic, anticholinergic, and antimotion sickness properties. Promethazine hydrochloride is a potent H1 receptor antagonist and a mAChR antagonist. It also has a certain affinity for 5-HT2A and 5-HT2C receptors[1][2].

Product Specifications

CAS Number

58-33-3

UNSPSC

12352005

Target

Adrenergic Receptor; Histamine Receptor; mAChR; Reference Standards

Type

Reference Standards

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/promethazine-hydrochloride-standard.html

Smiles

CC(N(C)C)CN1C(C=CC=C2)=C2SC3=CC=CC=C13.[H]Cl

Molecular Formula

C17H21ClN2S

Molecular Weight

320.88

References & Citations

[1]Fiorella D, et al. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. I: Antagonist correlation analysis. Psychopharmacology (Berl) . 1995 Oct;121 (3) :347-56.|[2]Kasai T, et al. Promethazine Hydrochloride Inhibits Ectopic Fat Cell Formation in Skeletal Muscle. Am J Pathol. 2017 Dec;187 (12) :2627-2634.|[3]McDonough JA, et al. Microcapsule-gel formulation of promethazine HCl for controlled nasal delivery: a motion sickness medication. J Microencapsul. 2007 Mar;24 (2) :109-16. |[4]Wink CS, et al. Effects of promethazine HCl on osteoporotic femora of adult castrated male rats. Acta Anat (Basel) .

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Isoform

5-HT2 Receptor

Available Sizes

Frequently Asked Questions

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