Antifungal agent 114
Antifungal agent 114 (Compound 19g) is an inhibitor for Cytochrome P450, that inhibits CYP1A2, CYP2C9, CYP2C19 CYP2D6 and CYP3A4 at 10 μM. Antifungal agent 114 exhibits antifungal activity against Cryptococcus neoformans, Candida and Aspergillus, with MIC [1].
Product Specifications
CAS Number
9007-83-4
UNSPSC
12352005
Target
Cytochrome P450; Fungal
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antifungal-agent-114.html
Smiles
O=C(C1=CC=C(C2=CC=C(Cl)C=C2F)S1)N(CC(O)(C3=CC=C(F)C=C3F)CN4N=CN=C4)C
Molecular Formula
C23H18ClF3N4O2S
Molecular Weight
506.93
References & Citations
[1]Wu X, et al., Design, synthesis and bioactivity evaluation of triazole antifungal drugs with phenylthiophene structure. Bioorg Chem. 2024 Sep 6;153:107785.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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