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Antifungal agent 114

Antifungal agent 114 (Compound 19g) is an inhibitor for Cytochrome P450, that inhibits CYP1A2, CYP2C9, CYP2C19 CYP2D6 and CYP3A4 at 10 μM. Antifungal agent 114 exhibits antifungal activity against Cryptococcus neoformans, Candida and Aspergillus, with MIC [1].

Product Specifications

CAS Number

9007-83-4

UNSPSC

12352005

Target

Cytochrome P450; Fungal

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antifungal-agent-114.html

Smiles

O=C(C1=CC=C(C2=CC=C(Cl)C=C2F)S1)N(CC(O)(C3=CC=C(F)C=C3F)CN4N=CN=C4)C

Molecular Formula

C23H18ClF3N4O2S

Molecular Weight

506.93

References & Citations

[1]Wu X, et al., Design, synthesis and bioactivity evaluation of triazole antifungal drugs with phenylthiophene structure. Bioorg Chem. 2024 Sep 6;153:107785.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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