STAT3-IN-15
STAT3-IN-15 is a potent and orally active STAT3 inhibitor against idiopathic pulmonary fibrosis (IPF) . STAT3-IN-15 inhibits STAT3 phosphorylation. STAT3-IN-15 also inhibits the migration and deformation of epithelial cells induced by TGF-β1 and inhibit epithelial-mesenchymal transition (EMT) [1].
Product Specifications
UNSPSC
12352005
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/stat3-in-15.html
Purity
98.99
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1CCN(CC1)CC2=CC(F)=C(C=C2F)F)C3=CC4=CC=CC=C4S3(=O)=O
Molecular Formula
C20H17F3N2O3S
Molecular Weight
422.42
References & Citations
[1]Wang Y, et al. Discovery of the novel Benzo[b]thiophene 1,1-dioxide derivatives as a potent STAT3 inhibitor against idiopathic pulmonary fibrosis. Eur J Med Chem. 2022 Nov 28;246:114953.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3
Available Sizes
Curated Selection
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