PBT434
PBT434 is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 prevents the loss of substantia nigra pars compacta neurons (SNpc) . PBT434 has the potential for the research of Parkinson’s disease (PD) [1].
Product Specifications
CAS Number
1232841-78-9
Product Name Alternative
ATH434
UNSPSC
12352005
Target
α-synuclein
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pbt434.html
Purity
98.86
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(C)C(CNCC)=NC2=C1C(Cl)=CC(Cl)=C2O.Br
Molecular Formula
C12H14BrCl2N3O2
Molecular Weight
383.07
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
α-synuclein Aggregation
Available Sizes
Frequently Asked Questions
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