NNMTi
Product Specifications
UNSPSC Description
NNMTi is a potent nicotinamide N-methyltransferase (NNMT) inhibitor (IC50=1.2 μM) and selectively binds to the NNMT substrate-binding site residues[2]. NNMTi promotes myoblast differentiation in vitro and enhances fusion and regenerative capacity of muscle stem cells (muSCs) in aged mice[1].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/nnmti.html
Purity
99.80
Solubility
DMSO : 20.83 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 2.27 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
C[N+]1=C2C=CC=C(N)C2=CC=C1.[I-]
Molecular Weight
286.11
References & Citations
[1]Harshini Neelakantan, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019 May;163:481-492.|[2]Harshini Neelakantan, et al. Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase. J Med Chem
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-131042/NNMTi-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-131042/NNMTi-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
42464-96-0
Available Sizes
Curated Selection
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