NNMTi

NNMTi is a potent nicotinamide N-methyltransferase (NNMT) inhibitor (IC50=1.2 μM) and selectively binds to the NNMT substrate-binding site residues[2]. NNMTi promotes myoblast differentiation in vitro and enhances fusion and regenerative capacity of muscle stem cells (muSCs) in aged mice[1].

Product Specifications

CAS Number

[42464-96-0]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Amine N-methyltransferase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/nnmti.html

Purity

99.64

Solubility

DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 2.27 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[N+]1=C2C=CC=C(N)C2=CC=C1.[I-]

Molecular Formula

C10H11IN2

Molecular Weight

286.11

Precautions

H315, H319, H320

References & Citations

[1]Harshini Neelakantan, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019 May;163:481-492.|[2]Harshini Neelakantan, et al. Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase. J Med Chem