Anti-CCR8 Antibody

Rabbit Polyclonal Antibody specific to CCR8 (EL)

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

C-C CKR-8, CC-CKR-8, CCR-8, CC chemokine receptor CHEMR1, CMKBRL2, Chemokine receptor-like 1, CKR-L1, GPR-CY6, GPRCY6, TER1, CD antigen CDw198

Gene Name

CCR8

Gene ID

1237

NCBI Gene ID

UniProt

P51685

Accession Number

NP_005192

Cellular Locus

Cell membrane; Multi-pass membrane protein.

Host

Rabbit

Reactivity

Human

Immunogen

Peptide corresponding to aa 183-201 of human CCR8 which is located in the second extracellular loop.

Target Antigen

C-C chemokine receptor type 8

Target

CCR8

Clonality

Polyclonal

Isotype

IgG

Type

Antibody

Applications

ELISA, WB

Field of Research

Infectious Disease

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. {PubMed:10540332, PubMed:9207005, PubMed:9469461, PubMed:9521068}.

Additionnal Information

Immunoblotting: use at 1:500-1:1,000 dilution. <br><br>Positive control: Tissue lysate from human spleen.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Specificity

This antibody recognizes human CCR8 (50 kD).

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

CCR8 is one of the chemokine receptors that are required as co- receptors for HIV infection. The genes encoding human and murine CCR8 have been cloned and designated TER1, CKR-L1, and ChemR1. The encoded seven transmembrane protein was identified as the receptor for human CC chemokine I-309 and renamed CCR8. Recently, CCR8 was found to serve as a coreceptor for diverse T-cell tropic, dual-tropic and macrophage- tropic HIV-1 strains. CCR8 mediates CC chemokine I-309 induced monocyte chemoattraction and HIV-1 envelope fusion and virus infection. CCR8 is expressed in spleen, thymus, and T lymphoblastic cell lines.