Tyrosinase-IN-27

Tyrosinase-IN-27 (compound 6f) is a tyrosinase (TYR) inhibitor (IC50: 0.88 μM) that statically quenches TYR. Tyrosinase-IN-27 increases the hydrophobicity of the enzyme microenvironment by binding to TYR, reducing the content of α-helices in the enzyme and changing its secondary structure. Tyrosinase-IN-27 can be used in the food industry to effectively inhibit the browning of lotus root slices[1].

Product Specifications

CAS Number

[2966803-96-1]

UNSPSC

12352005

Target

Tyrosinase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/tyrosinase-in-27.html

Solubility

10 mM in DMSO

Smiles

CCCC1=CC(OC2=C1C=CC(OCC3=CC(C(O)=CO3)=O)=C2)=O

Molecular Formula

C18H16O6

Molecular Weight

328.32

References & Citations

[1]He M, et al. Synthesis, anti-browning effect and mechanism research of kojic acid-coumarin derivatives as anti-tyrosinase inhibitors. Food Chem X. 2024 Jan 10;21:101128.